​What diseases can Stiripentol treat?

Stiripentol significantly reduces generalized seizures by enhancing GABAergic nerve conduction. Since its approval by the FDA, it has become an important drug to help patients control their seizures.

What diseases can Stiripentol treat?

A detailed understanding of the indications for a drug can help patients and doctors choose drugs carefully.

1. Indications

Stiripentol is used to treat seizures associated with Dravet syndrome (DS) and is suitable for patients taking clobazam who are older than 6 months and weigh more than 7 kg.

2. Restrictions

There are currently no clinical data to support the use of stiripentol as a single treatment for Dravet syndrome.

Knowing the conditions for which a drug is suitable can help patients make better drug choices, and drug interactions should be understood before using a drug for treatment.

What are the drug interactions of stiripentol?

Patients should also be aware of the drug interactions before deciding on medication.

1. The effect of other drugs on stitopentol

Potent CYP1A2, CYP3A4, or CYP2C19 inducers (e.g., rifampicin, phenytoin, phenobarbital, and carbamazepine) reduce the concentration of stiripentol. Concomitant use with these inducers should be avoided, or the dose should be adjusted.

2. Central nervous system depressants and alcohol

Concomitant use of Stiripentol with other central nervous system depressants or alcohol may increase the risk of sedation and drowsiness.

Patients and physicians should be concerned about drug interactions and be more mindful when using drugs.

Precautions for the use of Stiripentol?

There are some important considerations to be aware of before using Stiripentol to help better manage the course of treatment.

1. Drowsiness

Monitoring of the patient for drowsiness is recommended, especially when combined with clobazam. If lethargy occurs, consider reducing the initial dose of clobazam by 25%. If lethargy persists, a further reduction in the dose of clobazam and adjustment of other sedative anticonvulsants may be required. Inform patients that Stiripentol may affect mental alertness and avoid activities that require a high degree of concentration.

2. Decreased appetite and weight loss

Stiripentol may cause decreased appetite and weight loss. Growth in pediatric patients should be monitored, and valproate doses adjusted if necessary to alleviate these adverse effects.

Patients should pay close attention to their drug reactions during treatment and carefully identify whether they are related to drug use.

[Warm tips] During the use of stitopentol, please conduct regular examinations and pay attention to possible adverse reactions. If you experience any discomfort or abnormal symptoms, please contact your doctor promptly.