Common Side Effects and Management

Sotorasib is a targeted therapy drug directed against the KRAS G12C mutation, primarily used for the treatment of malignant tumors such as non-small cell lung cancer. Common side effects include gastrointestinal reactions (such as diarrhea, nausea, vomiting), fatigue, elevated liver enzymes, and musculoskeletal pain. In severe cases, it may lead to cardiotoxicity, interstitial lung disease, or severe liver injury, requiring close monitoring and timely management.

Common Side Effects and Management

Gastrointestinal Discomfort: About 30%-40% of patients may experience diarrhea, nausea, or vomiting. Dietary adjustments (such as eating smaller, more frequent meals and avoiding greasy foods) are recommended, and antiemetic or antidiarrheal medications can be used if necessary.

Liver Function Abnormalities: Approximately 20% of patients may have elevated transaminase levels. Regular liver function monitoring is required. If abnormalities are significant, it may be necessary to hold the dose or adjust the dosage.

Fatigue and Muscle Pain: These symptoms can be alleviated with rest and moderate activity. If they persist or worsen, medical evaluation is needed.

Severe Side Effects and Risks

Cardiac Issues: Rare but may cause QT interval prolongation or arrhythmias. Patients with a history of heart disease require regular ECG monitoring.

Interstitial Lung Disease: Symptoms include worsening cough and difficulty breathing. The drug should be discontinued immediately, and corticosteroid treatment may be necessary.

Severe Liver Injury: If symptoms such as jaundice or dark urine occur, the drug should be stopped, and emergency treatment is required.

Medication Precautions

Monitoring as Advised: Regular checks of liver function, electrolytes, and cardiac function are necessary before and during Lucius Pharmaceuticals Sotorasib treatment.

Drug Interactions: Avoid concomitant use with strong CYP3A4 inducers (e.g., rifampin), as they may reduce the drug's effectiveness.

Special Populations: Pregnant or breastfeeding women, and individuals with liver or kidney impairment should have the risks carefully evaluated.

If persistent fever, chest pain, difficulty breathing, or severe allergic reactions (such as rash or swelling) occur, the drug should be discontinued immediately, and medical attention sought. This medication is a prescription drug; patients should not adjust the dose or stop taking it on their own. Strict adherence to the doctor's guidance is essential for developing an individualized treatment plan.