What are the indications of Sotorasib?

Sotorasib, a novel small molecule targeted therapeutic agent, presents a promising treatment avenue for patients harboring the KRAS G12C mutation. The KRAS gene plays a pivotal role in intracellular signal transduction, encoding a protein that regulates cell growth, differentiation, and apoptosis. Upon occurrence of the G12C mutation in the KRAS gene, the encoded protein remains constitutively active, resulting in uncontrolled cell proliferation and differentiation.

What are the indications of Sotorasib?

Sotorasib is primarily indicated for the treatment of adult patients with locally advanced or metastatic NSCLC who have been confirmed to carry the KRAS G12C mutation through FDA-approved trials and have received at least one prior systemic therapy.

Sotorasib is a prescription medication that must be used under the guidance of a doctor. Individualized treatment plans will be formulated by physicians based on specific patient factors such as age, gender, disease severity, and genetic testing results. Patients are advised to strictly follow medical advice, adhere to dosing schedules, and refrain from altering medication doses or discontinuing treatment without consulting a healthcare professional. It is also essential for patients to be informed about relevant information regarding contraindications, dosing instructions, and potential drug interactions associated with Sotorasib.

What are the drug interactions of Sotorasib?

Sotorasib may interact with certain medications, potentially affecting efficacy or increasing the risk of adverse reactions. Prior to initiating Sotorasib therapy, patients should disclose all concomitant medications to their doctor for appropriate treatment planning.

1. Antacids

Concurrent use of antacids (e.g., proton pump inhibitors) with Sotorasib may decrease absorption and bioavailability, impacting therapeutic efficacy. Patients are advised to avoid simultaneous use of antacids during Sotorasib therapy or adjust dosing schedules under medical supervision.

2. CYP3A4 Substrates

Sotorasib serves as a CYP3A4 inhibitor and may interact with other drugs metabolized via the CYP3A4 pathway. Patients should inform their doctor of all medications being taken to assess potential interaction risks during Sotorasib administration.

3. P-glycoprotein (P-gp) Substrates

Sotorasib may enhance the absorption of certain P-gp substrates, increasing the risk of altered efficacy or adverse reactions. Patients should monitor potential interactions with other P-gp substrate medications and make adjustments under the guidance of a doctor.

[warm tips] During Sotorasib treatment, patients are advised to maintain a positive mindset, and balanced lifestyle habits, and avoid excessive physical or emotional stress. Monitoring one's body for any signs of discomfort or adverse reactions is crucial, and prompt medical consultation should be sought in such cases.