What are the drug interactions of Pemigatinib?

Pemigatinib is the world's first targeted therapy for cholangiocarcinoma.

What are the drug interactions of Pemigatinib?

The metabolic process of Pemigatinib may be influenced by two key metabolic enzymes in the liver: CYP3A4 and CYP2C9. When Pemigatinib is used concomitantly with inhibitors of CYP3A4 or CYP2C9, these inhibitors may slow down the rate of metabolism of Pemigatinib in the body, which in turn can lead to abnormally high blood concentrations. This increase in blood levels may exacerbate the toxic side effects of Pemigatinib, posing unnecessary health risks to patients.

While taking Pemigatinib, patients should strictly avoid simultaneous use with strong inhibitors of CYP3A4 or CYP2C9. If a combination of these drugs is indeed needed, it must be done under the guidance of a physician, and the dose or dosing regimen of Pemigatinib may need to be adjusted to ensure the safety and effectiveness of the medication. Doctors will develop a personalized medication plan based on the patient's specific situation and drug metabolism characteristics to minimize the risk of drug interactions.

Which foods Pemigatinib interacts with

Patients should provide a detailed history of medications and allergies to their doctor before taking medication to avoid drug-drug interactions. Certain foods or drinks may also affect the absorption and metabolism of Pemigatinib, and patients should follow their doctor's advice to avoid foods or drinks that interact with the drug while taking the medication.

Some components in grapefruit may affect the metabolic process of the drug, and a large intake of grapefruit or drinking grapefruit juice should be avoided during the use of Pemigatinib to avoid increasing the risk of adverse reactions.

Monitoring and management of patients during the use of Pemigatinib

During the use of Pemigatinib, the patient's indicators and his own condition should be paid attention to in time so that adjustments can be made at any time.

1. In the process of using Pemigatinib, doctors should regularly monitor the patient's liver function, kidney function blood indicators, etc., to find and deal with possible adverse reactions in a timely manner.

2. If there is blurred vision, floating objects in the eyeballs, flashes of light, or other serious vision changes, as well as serious side effects such as muscle cramps, numbness, or dry mouth, patients should stop the drug immediately and seek medical attention.

【Warm tips】When patients buy generic drugs, they should choose formal channels to ensure the quality and safety of the drugs. Avoid purchasing counterfeit products from informal sources.