Drug interactions of Futibatinib

1 Effect of Other Drugs on Futibatinib  

Futibatinib is a substrate of CYP3A and P-gp.  

Dual P-gp and Strong CYP3A Inhibitors

Avoid concomitant use of drugs that are dual P-gp and strong CYP3A inhibitors with Futibatinib.  

Concomitant use of drugs that are dual P-gp and strong CYP3A inhibitors with Futibatinib may increase  futibatinib exposure, which may increase the incidence and severity of  adverse reactions.

Dual P-gp and Strong CYP3A Inducers  

Avoid concomitant use of dual P-gp and strong CYP3A inducers with Futibatinib.  

Concomitant use of drugs that are dual P-gp and strong CYP3A inducers may decrease futibatinib exposure, which may reduce the efficacy of Futibatinib.

2 Effect of Futibatinib on Other Drugs  

Futibatinib is an inhibitor of P-gp and BCRP.  

P-gp or BCRP Substrates:

Consider more frequent monitoring for adverse reactions associated with concomitantly administered drugs that  are sensitive substrates of P-gp or BCRP and reduce the dose of these drugs per their Prescribing Information.

Futibatinib may increase exposure of drugs that are substrates of P-gp or BCRP.

FDA，2022.09