What interactions can occur with other medications

Exkivity reduces the growth of non-small cell lung cancer by binding to and inhibiting EGFR exon 20 insertion mutations.

What interactions can occur with other medications?

Exkivity may cause changes in the electrical activity of your heart called QTc prolongation and Torsades de Pointes. QTc prolongation can cause irregular heartbeats that can be life-threatening and may lead to death. Your healthcare provider will check the electrical activity of your heart with a test called an electrocardiogram (ECG) and do blood tests to check your electrolytes before starting, and during treatment.

Clinical Impact of drug interactions with Exkivity

Exkivity can cause QTc interval prolongation. Coadministration of Exkivity with drugs known to prolong the QTc interval may increase the risk of QTc interval prolongation.

Exkivity can cause life-threatening heart rate-corrected QT (QTc) prolongation, including Torsades de Pointes, which can be fatal. In the 250-patient subset of the pooled Exkivity safety population who had scheduled and unscheduled electrocardiograms (ECGs), 1.2% of patients had a QTc interval >500 msec and 11% of patients had a change-from-baseline QTc interval >60 msec. Grade 4 Torsades de Pointes occurred in 1 patient (0.4%).

Management of drug interactions with Exkivity

Avoid concomitant use of other medications known to prolong the QTc interval with Exkivity. If concomitant use is unavoidable, monitor the QTc interval more frequently with ECGs.Depending on the severity of QTc prolongation, Exkivity was suspended, tapered, or permanently discontinued.

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