What medications does capmatinib interact with?

Capmatinib is an oral, selective, ATP-competitive c-Met kinase inhibitor that inhibits c-Met kinase for the treatment of metastatic non-small cell lung cancer with mutations in MET exon 14.

What medications does capmatinib interact with?

With the successful launch of capmatinib in the domestic market and its wide application in clinical practice, doctors and patients should pay close attention to the possible interaction of the drug.

1. CYP3A inducer

CYP3A inducers may reduce plasma concentrations of capmatinib and weaken antitumor activity. To maintain the efficacy of the drug, it is recommended to avoid concomitant use with these inducers.

Common CYP3A inducers include, but are not limited to, rifampicin, rifapentine, phenytoin, carbamazepine, barbiturates, and St. John's wort.

2. CYP1A2 substrate

Simultaneous use of CYP1A2 substrates may lead to an increase in blood concentrations of these substrates, which may trigger serious adverse effects. Concomitant use with CYP1A2 substrate should be avoided as much as possible. Common CYP1A2 substrates include, but are not limited to, caffeine, aflatoxin B1, and paracetamol.

What is the dosage of capmatinib?

Understanding the dosage requirements of the drug is very important for doctors and patients to develop a drug treatment plan, which is organized according to the drug label as follows:

The recommended dose of capmatinib is 400 mg orally twice daily. Can be taken before or after meals without special adjustments. Tablets should be swallowed whole, not broken, crushed, or chewed. If you miss a dose or vomit after taking the medicine, you don't need to make up the dose, and you can take the next dose as scheduled for your next dose.

Why choose the drugs made by Lucius?

The Lucius Pharmaceutical factory covers an area of 25,000 square meters and is equipped with advanced production facilities and equipment. The product line covers anti-tumor drugs, cardiovascular drugs, hematology drugs, diabetes drugs, dermatology drugs, men's health drugs and anti-aging drugs, etc., providing more than 200 generic drug varieties.

The factory strictly abides by the international Good Manufacturing Practice (GMP), strictly controls every link of raw material procurement, production process and finished product inspection, and has a perfect quality traceability system to ensure the controllability and traceability of drug quality.

[Warm tips] Patients should strictly follow the doctor's guidance when using capmatinib and maintain a healthy lifestyle and eating habits, which can help improve the efficacy of the drug and improve overall health.