Which drugs interact with Alpelisib

Apellix is a drug used to treat specific types of breast cancer, and its use, storage, and daily precautions are critical for patients.

Which drugs interact with Alpelisib

Interactions between apellix and other drugs may affect its efficacy or increase the risk of adverse effects.

CYP3A4 inducers

Strong CYP3A inducers, such as rifampicin, rifapentine, phenytoin, carbamazepine, barbiturates, and St. John's wort, can significantly reduce the blood concentration of apellix and reduce the efficacy. Therefore, concomitant use with these drugs should be avoided and, if not, the dose of apelix should be increased appropriately.

BCRP inhibitors

BCRP inhibitors may increase the concentration of apellix, thereby increasing the risk of toxicity. Therefore, BCRP inhibitors should be avoided in patients receiving apellix and should be closely monitored for adverse effects if necessary.

CYP2C9 substrate

Combination with CYP2C9 substrates such as warfarin can reduce plasma concentrations of these drugs, possibly affecting their activity. Therefore, when apellix is used in combination with CYP2C9 substrates, plasma concentrations of CYP2C9 substrates need to be closely monitored.

How should Alpelisib be stored

Proper storage conditions are essential to maintain the stability and efficacy of apellix.

Temperature control

Apellix should be stored in an environment between 20°C and 25°C with a permissible temperature deviation of 15°C to 30°C. Avoid extreme heat or cold environments, freezing may cause changes in drug structure and efficacy.

Moisture and moisture resistant

Choose a dry, well-ventilated place to store apellix to prevent the medicine from getting wet. Changes in humidity can negatively affect the stability of the drug.

Store away from light

Apellix should be kept away from direct sunlight, which may adversely affect the stability of the drug. It should be protected from light or in an opaque container.

Apellis's daily precautions

Knowing and following the daily precautions for apellix can help patients use the drug safely and effectively.

Dosage and frequency of medication

The recommended dose of apellix is 300 mg (two 150 mg tablets) taken once daily with food. Patients should take the tablets at about the same time each day, swallowing them whole, and should not chew, crush, or separate the tablets.

Adverse reaction monitoring

Patients taking apellix may experience a variety of adverse effects, such as hyperglycemia, diarrhea, rash, etc. Patients should monitor their blood glucose, liver function, and lung condition regularly and report any discomfort to their doctor promptly.

Guidance on medication for special populations

Pregnant and lactating women, people of reproductive potential, children, and older patients should be given special care when using apellix. Pregnant and lactating women should take the drug under the guidance of a doctor, and people of reproductive potential should use effective contraception. Safety and efficacy in children and older patients have not been established and should be used with caution under physician guidance.

Apellix is a drug used to treat specific breast cancers, and its use, storage, and daily precautions must be strictly adhered to. By understanding drug interactions, storing the drug correctly, and following daily precautions, patients can use the drug more safely and effectively, improving treatment outcomes and reducing the risk of adverse effects.