Anamorelin

Anamorelin has an effect on the ghrelin receptor GHS-R1a (growth hormone release promoter receptor type 1a). The drug boosts the secretion of growth hormone (GH) by activating GHS-R1a and promoting appetite, resulting in weight gain.

The drug binds to recombinant human GHS-R1a and acts on rat pituitary cells to promote GH secretion (in vitro). This drug increases plasma GH concentrations in rats by a single oral administration. By repeated oral administration to rats, the drug increases food intake and body weight.

Anamarin hydrochloride is a new type of cancer cachexia treatment drug, which can effectively alleviate the symptoms of cancer cachexia, mainly acting on the nervous and metabolic systems in the body through specific signaling pathways, improving the patient's appetite and food digestion and absorption ability, and promoting the protein synthesis and muscle growth in the patient's body.

1. Main ingredient

Anamarin hydrochloride

2. Applicable people

Patients with unresectable progression/recurrence of non-small cell lung cancer, gastric cancer, pancreatic cancer, colorectal cancer, and cancer cachexia that do not respond to satisfactory nutritional therapy are also suitable for patients who have lost >5% of their body weight within 6 months and have loss of appetite and other discomforts.

3. Use in Specific Populations

3.1 Pregnant and lactating women

Should only be given if the benefits of treatment are considered to outweigh the dangers. In addition, the placental transmissibility of anamarin hydrochloride is not known, but considering factors such as high fat solubility and weak alkalinity, it is possible to enter the fetus through the placenta or migrate to breast milk.

3.2 Pediatric Use

There are no clinical trials for children, but it is recommended that children take the drug under the guidance of a doctor.

3.3 Geriatric Use

It is necessary to carefully administer the drug while observing the condition of the elderly patient, and there may be a decrease in physiological function (kidney function, liver function, immune function, etc.).

4. Storage

Store at room temperature.

5. Pharmacokinetics

A single dose of Anamorelin 100mg or a single intravenous dose of Anamorelin 10mg in healthy adults has an absolute bioavailability of 37.0% of AnamorelinIn human plasma, the protein binding rate is 97.3-98.3%.

fromJP,2023.02