Correct dosage, usage, and dose adjustment of Abrocitinib

Correct dosage, usage, and dose adjustment of Abrocitinib

Abrocitinib is an oral tablet that can be taken with or without food. The recommended starting dose for adults and adolescents (12-17 years) weighing at least 59 kg is 100 mg or 200 mg once daily, as determined by a physician. A lower starting dose (100 mg once daily) may be needed in the following situations: age 65 years or older, having certain medical conditions, or for adolescents weighing between 25 kg and 58 kg. If moderate to severe kidney problems are present, or if certain other medications are being taken, the starting dose may be 50 mg or 100 mg once daily. If no improvement is seen after 24 weeks of treatment, the physician may decide to permanently discontinue the medication. If blood tests show that white blood cell or platelet counts are too low, treatment may be temporarily or permanently interrupted. Do not adjust the dose or stop the medication on your own.

How to take Abrocitinib, and management of missed or overdose

You should swallow the tablet whole with a glass of water. Do not split, crush, or chew the tablet, as this may affect drug absorption. It is recommended to take the medication at the same time each day to help you remember. If you forget to take a dose, take it as soon as you remember. However, if it is less than 12 hours until your next scheduled dose, skip the missed dose and take the next dose at the usual time. Do not take a double dose to make up for a missed one. If you suspect an overdose, contact your doctor immediately, as you may experience the side effects described below. Do not stop treatment without first discussing it with your doctor.

Possible side effects and storage of Abrocitinib

Abrocitinib may cause a range of side effects. A very common side effect (affecting more than 1 in 10 people) is nausea. Common side effects (affecting up to 1 in 10 people) include: cold sores and other herpes simplex virus infections, vomiting, abdominal pain, headache, dizziness, acne, and a rise in blood creatine kinase levels seen in blood tests. Uncommon side effects (affecting up to 1 in 100 people) include: pneumonia, decreased platelet count, decreased white blood cell (lymphocyte and neutrophil) counts, and high cholesterol seen in blood tests. Serious side effects include shingles (painful blistering rash with fever) and blood clots in the lungs, legs, or pelvis (manifested as leg swelling/pain, chest pain, or shortness of breath). If you experience any of these symptoms, seek immediate medical attention. For storage, keep this medication out of the sight and reach of children, and do not use it after the expiry date stated on the packaging. No special storage conditions are required. If you experience any side effects, consult your doctor or pharmacist.