What are the side effects of venetoclax?

Venetoclax is the world's first approved selective inhibitor of Bcl-2 that induces apoptosis in cancer cells by highly inhibiting Bcl-2 protein. It has a weak affinity for Bcl-xL and Bcl-W, reducing the risk of platelet damage.

What are the side effects of venetoclax?

Venetoclax may also have a series of adverse reactions during use, the severity of these adverse reactions varies from person to person, according to the drug label, the common adverse reactions are as follows:

1. Thrombocytopenia

The number of platelets decreases, increasing the risk of bleeding. Patients may experience symptoms such as easy bruising, nosebleeds, or bleeding gums, and may require platelet transfusions in severe cases.

2. Diarrhea

Patients may experience frequent loose or watery stools, which can lead to dehydration. Symptoms can be relieved by dietary modifications, rehydration, or the use of antidiarrheal medications.

Venetoclax for special populations?

In addition to knowing the side effects of the drug, it is also important for the patient to know the specific user group of the drug before purchasing and using the drug:

1. Medication for the elderly

There are insufficient data from studies in older people with AML to determine whether there is a difference in response between patients aged 65 years and older and younger patients. Use with caution.

2. Females and males of childbearing age

Venetoclax may cause damage to the fetus, and women of childbearing age should use effective contraception during use, and men should be aware of the possible reproductive risks.

What are the precautions for venetoclax?

When considering venetoclax for treatment, the following considerations are critical:

1. Tumor lysis syndrome

Patients treated with venetoclax may develop tumor lysis syndrome (TLS), which can lead to serious complications, including fatal events or kidney failure requiring dialysis. Doctors closely monitor the patient's condition to detect and manage this risk as early as possible.

2. Infection

Patients treated with venetoclax may develop serious infections, including fatal pneumonia and sepsis. These infections may affect the effectiveness of treatment and the overall health of the patient.

[Warm tips] Doctors should carefully assess the patient's specific situation and monitor the patient's drug concentration and kidney function frequently. Patients should also pay attention to follow the doctor's medication guidance and follow the course of medication on time.