What are venetoclax drug interactions?

Venetoclax reduces the viability of cancer cells by highly selectively inhibiting the function of the Bcl-2 protein. Venetoclax has a low effect on platelets and has been approved for the treatment of a variety of hematologic tumors.

What are venetoclax drug interactions?

Understanding drug interactions to avoid unnecessary drug risks should be noted by both physicians and patients during medication treatment.

P-gp substrates

The use of venetoclax can lead to an increase in blood concentrations of P-gp substrate drugs, which may increase the risk of toxicity of these drugs. In order to reduce the harm caused by this interaction, it is recommended to avoid the simultaneous use of venetoclax and P-gp substrates as much as possible.

If it is true that the combination of these two drugs cannot be avoided, it is recommended to administer the P-gp substrate alone at least 6 hours before taking venetoclax to reduce the risk of toxicity.

What are the precautions for venetoclax use?

Before taking the drug, it is important for patients to understand the precautions of the drug in detail to avoid the risks caused by blind medication.

1. Risk of infection

During venetoclax treatment, patients are at significantly increased risk of infections, including potentially fatal and serious infections such as pneumonia and sepsis. These infections can affect the patient's treatment process and become life-threatening. Doctors need to pay special attention to the symptoms of infection and take effective anti-infective treatment measures in a timely manner.

2. Immunization

There are currently no data on the safety and efficacy of live attenuated vaccines administered during or after venetoclax treatment. Patients are advised to avoid live attenuated vaccines during and around treatment with venetoclax until B-cell function is restored. Considering that the effectiveness of the vaccine may be affected by treatment, patients are advised to be cautious about vaccinations during this period and follow the doctor's guidance.

What are some common adverse drug reactions to venetoclax?

When using this drug, patients must be aware of some common adverse drug reactions:

1. Fatigue

During venetoclax treatment, people may feel extremely tired or lack energy, often requiring rest and adjustment of activity.

2. Edema

Swelling in the limbs or other parts of the body, usually due to fluid retention, may need to be managed with diuretics or dietary modifications.

[Warm tips] Patients should give feedback to the doctor in time about their physical discomfort and abnormal reactions, which will help the doctor to understand the patient's condition in a timely manner, and adjust the treatment plan or take necessary treatment measures according to the specific situation.