Sotorasib Dosage Guide: 960 mg Daily Intake and Modification Schedule

The usual recommended dose of sotorasib is 960 mg (8 tablets x 120 mg) once daily, taken on an empty stomach at least 1 hour before or 2 hours after eating. Specific usage must be strictly followed as directed by your doctor, and the dosage should be adjusted based on the patient's liver function, adverse reactions, etc.

Usage and Dosage Directions for Use

1. Oral tablets, taken at the same time daily. It is recommended to swallow the tablet whole without breaking or chewing. If a dose is missed and more than 6 hours have passed since the next scheduled dose, take it; if less than 6 hours have passed, skip the missed dose to avoid doubling the dosage.

2. Should be taken 1 hour before or 2 hours after a meal. Food may affect drug absorption. If gastrointestinal reactions require taking it with food, consult your doctor beforehand to adjust the regimen.

3. The standard dose is 960 mg/day, 8 tablets (120 mg/tablet) each time. Dosage adjustments should be based on liver function and the severity of adverse reactions. For example, patients with moderate to severe liver damage may need to reduce the dose to 480 mg or discontinue the medication.

Dosage Adjustment and Special Cases: 

Liver Function Abnormalities: Patients with baseline liver dysfunction (e.g., Child-Pugh B/C) should have their dose reduced to 480 mg/day, and transaminase and bilirubin levels should be monitored regularly during treatment.

Adverse Reactions Management: If grade ≥3 adverse reactions occur (e.g., diarrhea, elevated liver enzymes), medication should be discontinued until recovery to grade ≤1, then the dose should be reduced to 480 mg or 720 mg/day as needed. If 480 mg is intolerable, the medication should be permanently discontinued.

Precautions and Drug Interactions 

1. Avoid concurrent use with strong CYP3A4 inducers (e.g., rifampin, phenytoin), as this may reduce the efficacy of Lucius Pharmaceuticals Sotorasib. If necessary, alternative medications should be used or monitoring should be intensified.

2. Liver function should be checked every 3 weeks during the initial treatment phase, and monthly thereafter; immediate medical attention is required if symptoms such as jaundice or darkening of urine occur.

3. Contraindicated in pregnant and lactating women; elderly patients do not require dose adjustment, but tolerability should be closely monitored.

Management of Common Adverse Reactions:

Diarrhea: Mild cases can be treated with oral rehydration and dietary adjustments; moderate to severe cases require discontinuation of the medication and the use of antidiarrheal medication.

Hepatotoxicity: If ALT/AST levels are elevated >5 times the upper limit of normal or bilirubin levels are >3 times the upper limit, permanent discontinuation of the medication is necessary.

Musculoskeletal pain: Symptomatic treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) is recommended; if pain persists and worsens, medical evaluation is required.

In summary, sotorasidub treatment requires individualized management. Patients should strictly adhere to the prescription, have regular check-ups, and promptly report any abnormal symptoms to ensure safe and effective treatment.