What should I pay attention to when using Selpercatinib?

Selpercatinib is a targeted drug designed for the treatment of non-small cell lung cancer, targeting RET gene mutations, and the mechanism of action is to limit the spread of cancer cells by inhibiting RET kinase, and is usually used in patients who do not respond to other treatments.

What should I pay attention to when using Selpercatinib?

There are several important considerations to be aware of when treating with Selpercatinib.

1. Ophthalmic toxicity

Selpercatinib may cause retinal pigment epithelium detachment (RPED), with symptoms including blurred vision, floaters, etc. Routine monitoring (eg, optical coherence tomography) is not performed in clinical trials, but the asymptomatic incidence of RPED is unknown.

2. Hyperphosphatemia and soft tissue mineralization

The use of Selpercatinib may cause hyperphosphatemia, resulting in calcification and calcium deposition of soft tissues and skin. An increase in phosphate levels is one of the side effects of the drug.

What is the medication for selpatinib in special populations?

When using Selpercatinib, special populations need to pay special attention to the following medication guidelines.

1. Patients with liver injury

Patients with severe liver impairment should reduce the dose of Selpercatinib according to their doctor's recommendation to reduce the side effects caused by the drug. For patients with mild to moderate hepatic impairment, dose adjustment is usually not necessary, but any adverse effects during treatment should be closely watched. If there is a change in the patient's liver function, the treatment regimen should be adjusted promptly.

2. Pediatric use

The safety and efficacy of Selpercatinib in children under 12 years of age have not been fully validated. Extreme caution should be taken when using the drug in children, a detailed assessment should be carried out before treatment, carried out under strict supervision by a professional doctor, to avoid possible risks and adverse reactions.

What are the adverse effects of Selpercatinib?

It is important to be aware of the possible adverse effects of Selpercatinib, and here are some common side effects and considerations.

1. Anemia

Symptoms of anemia include fatigue, dizziness, shortness of breath, etc., which may affect the patient's life. Your doctor may recommend iron or other nutrients and regular monitoring of your hemoglobin levels to manage anemia.

2. Constipation

Constipation problems can cause patients to feel bloated and uncomfortable, affecting gastrointestinal function. Patients should increase their dietary fiber intake, drink plenty of water, and use laxatives as recommended by their doctors to promote normal bowel movements.

[Warm tips] If you experience any discomfort during the use of Selpercatinib, please contact your doctor for help.