What are the drug interactions of Selpercatinib?

Selpercatinib is a drug that targets mutations in the RET gene and is suitable for a variety of cancers caused by RET fusions or mutations. It stops the growth and spread of tumors by inhibiting the activity of RET kinase. Selpercatinib has shown promising efficacy in a variety of solid tumors and gene mutation types.

What are the drug interactions of Selpercatinib?

When using this drug, special attention should be paid to interactions with other drugs to avoid affecting the therapeutic effect or causing adverse reactions.

1. Strong and moderate CYP3A inhibitors

The use of strong or moderate CYP3A inhibitors increases plasma concentrations of Selpercatinib and may increase the risk of adverse effects, such as prolonged QTc intervals, and should be avoided if possible. If a combination is necessary, it is recommended to lower the dose of Selpercatinib and monitor the QT interval more frequently.

2. Some P-gp substrates

Selpercatinib is a P-gp inhibitor, and combination with P-gp substrates may increase plasma concentrations of these drugs and increase the risk of associated adverse effects. It is recommended to avoid the combination use, and if it cannot be avoided, it should be adjusted according to the instructions for use of the P-gp substrate drug.

What diseases is Selpercatinib suitable for treatment?

Before using Selpercatinib, you should know the following drugs for which the disease is indicated.

1. RET fusion-positive non-small cell lung cancer (NSCLC)

Selpercatinib is indicated for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with an FDA-approved assay confirmed RET gene fusion.

2. RET mutant medullary thyroid cancer (MTC)

Indicated for the treatment of adult and pediatric patients 2 years of age and older who have an FDA-approved test-confirmed RET mutation and who require systemic therapy for advanced or metastatic medullary thyroid cancer.

What are the adverse effects of Selpercatinib?

Understanding the potential adverse effects of Selpercatinib can help patients better manage the course of treatment, and here are the common side effects.

1. Stomatitis

The mouth may be sore, red, swollen or painful, affecting eating and speaking. The use of nonalcoholic mouthwashes and local anesthetic medications can reduce discomfort and avoid spicy or acidic foods.

2. Dry eye syndrome

Dry and uncomfortable eyes can cause blurred vision. Symptoms can be relieved with artificial tears or moisturizing eye drops, consult an ophthalmologist if necessary.

[Warm tips] Pay attention to personal hygiene to avoid infection, especially if the immune system may be affected during treatment. Washing your hands frequently and keeping your environment clean can help reduce the risk of infection.