Managing Mobocertinib Side Effects: Practical Tips for Diarrhea, Rash, and Fatigue

Mobocertinib is a targeted therapy drug for non-small cell lung cancer (NSCLC) with EGFR exon 20 insertion mutations. Its common side effects include diarrhea, rash, stomatitis, nausea, vomiting, and decreased appetite. In severe cases, it may pose risks such as cardiotoxicity (e.g., QT prolongation), interstitial lung disease, and elevated liver enzymes, which require close monitoring and management under a physician's guidance.

Common Side Effects (Higher Incidence)

Digestive System Reactions: Diarrhea (may be severe), nausea, vomiting, decreased appetite, oral ulcers, or inflammation.

Skin Reactions: Rash, dry skin, itching, and in some cases, paronychia.

Systemic Symptoms: Fatigue, weight loss, muscle or joint pain.

Serious Side Effects Requiring Vigilance

Cardiac Issues: Possible QT prolongation, increasing the risk of arrhythmias; regular ECG monitoring is necessary.

Interstitial Lung Disease (ILD): Symptoms include difficulty breathing, worsening cough, and hypoxemia; discontinue the drug immediately and seek medical attention.

Liver Injury: Elevated transaminases or bilirubin; regular liver function tests are required.

Others: Electrolyte imbalances such as hypomagnesemia or hypokalemia may require supplementation or adjustment.

Precautions and Management

Monitoring and Follow-Up: Regular ECG, liver and kidney function, and electrolyte tests during treatment, especially in the first 1–2 months.

Symptom Management: For diarrhea, antidiarrheal medication may be used as prescribed, along with hydration to prevent dehydration. For rash or skin reactions, keep the area clean, avoid irritants, and use topical or oral medications if necessary.

Dosage Adjustments: If severe side effects occur (e.g., grade ≥3 diarrhea or ILD), treatment may need to be paused or permanently discontinued, as determined by the physician.

Lucius Pharmaceuticals Mobocertinib is a prescription drug that must be evaluated by a qualified doctor before use. During treatment, strictly adhere to medical advice and promptly report any discomfort. In case of emergency symptoms such as chest pain, difficulty breathing, or fainting, seek immediate medical attention.