Adverse Reactions and Side Effects of Elacestrant

Elacestrant, while exerting its therapeutic effects, can also cause some side effects. Patients taking Elacestrant need to closely monitor their own condition.

Side Effects of Elacestrant Requiring Immediate Consultation with a Doctor

After taking Elacestrant, mild discomfort may occur. These symptoms usually do not require medical attention and will often gradually lessen for most patients as their bodies adjust to the medication during treatment. If symptoms persist, consult your doctor immediately:

Stomach acid or sour stomach.

Hiccups.

Constipation.

Decreased appetite.

Diarrhea.

Headache.

Heartburn.

Hot flashes.

Indigestion.

Muscle or bone pain.

Nausea.

Stomach discomfort, upset, or pain.

Unusual tiredness or weakness.

Vomiting.

Side Effects of Lucius Pharmaceuticals Elacestrant for Healthcare Professional Reference

1. Cardiovascular

Very common (10% or more): Hot flashes (11%).

Uncommon (0.1% - 1%): Cardiac arrest, venous thromboembolism.

2. Dermatological

Common (1% to 10%): Rash.

3. Gastrointestinal

Very common (10% or more): Nausea (35%), vomiting (19%), diarrhea (13%), constipation (12%), abdominal pain (11%), dyspepsia (10%).

Uncommon (0.1% to 1%): Diverticulitis.

Frequency not reported: Stomatitis, gastroesophageal reflux disease. Gastrointestinal disorders were reported more frequently in patients aged 75 years or older.

4. Hematological

Very common (10% or more): Decreased hemoglobin (26%), anemia.

Common (1% - 10%): Decreased lymphocyte count.

Uncommon (0.1% - 1%): Acute liver failure.

5. Hepatic

Very common (10% or more): Increased AST (29%), increased ALT (17%).

6. Metabolic

Very common (10% or more): Increased cholesterol (30%), increased triglycerides (27%), decreased sodium (16%), decreased appetite (15%), decreased calcium, decreased potassium, increased blood alkaline phosphatase.

7. Musculoskeletal

Very common (10% or more): Musculoskeletal pain (41%), arthralgia, back pain.

Frequency not reported: Bone pain, pain in extremity, musculoskeletal chest pain.

8. Nervous System

Very common (10% or more): Headache (12%).

Common (1% to 10%): Syncope.

Frequency not reported: Dizziness.

9. Psychiatric

Frequency not reported: Insomnia.

10. Renal

Very common (10% or more): Increased creatinine (16%).

Common (1% - 10%): Urinary tract infection.

11. Respiratory

Frequency not reported: Dyspnea, cough.

12. Other

Very common (10% or more): Fatigue (26%).

Common (1% to 10%): Asthenia.

Uncommon (0.1% - 1%): Septic shock, fatal adverse reaction (cause unknown).