Precautions for Using Cabozantinib

Doctors should conduct regular follow-ups to evaluate the efficacy of the medication, and adverse reactions may need to be monitored through blood and urine tests.

Precautions for Using Cabozantinib

Use of this medication during pregnancy may cause fetal harm. Females of childbearing potential must undergo a medical examination to confirm they are not pregnant before treatment; strict contraception is required during treatment and for at least 4 months after the last dose. Inform your doctor immediately if pregnancy is suspected.

Seek emergency medical attention immediately if you experience severe abdominal pain, nausea, coughing, or choking when eating or drinking—this may indicate intestinal perforation or fistula formation.

This medication increases the risk of bleeding. Seek emergency medical attention immediately if you experience hemoptysis, gum bleeding, difficulty breathing/swallowing, dizziness, menorrhagia/vaginal bleeding, epistaxis, persistent wound bleeding, red/dark brown urine, or black stools. Avoid strenuous exercise and situations with a high risk of injury; brush your teeth gently and use dental floss cautiously; handle sharp objects such as razors and nail clippers with care.

This medication increases the risk of thrombosis. Seek emergency medical attention immediately if you experience swelling/pain in the limbs/abdomen, chest pain, difficulty breathing, loss of sensation, confusion, impaired limb control or speech.

Seek emergency medical attention immediately if you experience chest pain/discomfort, nausea, pain in the upper limbs/jaw/back/neck, sweating, or vomiting—this may indicate a myocardial infarction.

Administration of Cabozantinib

Cabozantinib is available in two formulations: Cabometyx tablets and Cometriq capsules, which are approved for different indications and are not interchangeable.

Taking Cabometyx Tablets

Take on an empty stomach, at least 1 hour before a meal or 2 hours after a meal.

Taking Cometriq Capsules

Take without food, ensuring a 2-hour interval before eating and a 1-hour interval after eating.

Tablets and capsules must be swallowed whole—do not crush, chew, or divide.

During treatment, avoid consuming grapefruit and taking St. John’s Wort, as both may affect the efficacy of the medication. If a dose is missed, take it as soon as possible within 12 hours before the next scheduled dose.

Store the medication at room temperature (20–25°C/68–77°F), with a permitted minor fluctuation range of 15–30°C (59–86°F).

Contraindications During Cabozantinib Treatment

Cabozantinib is metabolized by the CYP3A4 enzyme and may interact with CYP3A4 inhibitors and inducers.

Avoid the use of potent CYP3A4 inhibitors, as they may increase cabozantinib blood concentrations and raise the risk of adverse reactions. If concurrent use is necessary, adjust the cabozantinib dose according to dosage guidelines.

Similarly, avoid the use of moderate to potent CYP3A4 inducers, as they may reduce the efficacy of cabozantinib. If concurrent use is necessary, appropriately increase the cabozantinib dose.