What side effects may occur with Cabozantinib use?

After administration, necessary therapeutic effects may occur, and adverse reactions may also be triggered. Not all adverse reactions will manifest. If any adverse reaction occurs, seek medical attention promptly.

What side effects may occur with Cabozantinib use?

Adverse Reactions Requiring Immediate Medical Attention

Common

Anxiety, blurred vision, burning/numbness/tingling/pain, chest pain, confusion, constipation, cough, dark urine, skin hyperpigmentation, decreased urine output, diarrhea, dyspnea/dysphagia, dizziness, dry mouth, dry skin/hair, syncope, chills, alopecia, headache, hoarseness, tachycardia, dizziness, decreased appetite, depressed mood, muscle cramps/twitching/stiffness, nausea and vomiting, nervousness, painful swelling of the extremities, pain in the chest/groin/legs (especially the calves), tachypnea, painful skin redness and swelling, desquamation of the palms and soles, sudden severe headache, rash/ulcers, cardiac arrhythmia, slurred speech, abdominal pain, sudden ataxia, sudden severe weakness/numbness of the extremities, sunken eye sockets, thirst, unsteady gait, abnormal fatigue, visual changes, limb weakness, weight gain, skin wrinkling, jaundice of the sclera/skin.

Uncommon

Bleeding gums, bloody/black stools, hemoptysis, heartburn, heaviness in the jaw, menorrhagia/vaginal bleeding, dyspepsia, loose teeth, emotional/mental abnormalities, muscle spasms of the extremities/facial muscles, epistaxis, numbness and tingling around the mouth/fingertips/feet, painful swelling and numbness of the oral/jaw region, paralysis, persistent wound bleeding, red/dark brown urine, seizures, severe abdominal pain/cramping/burning, tremors, dyspnea, vomiting coffee-ground material (persistent and severe).

Rare

Chest tightness, distended jugular veins, abnormal color vision, diplopia, halos in vision, cardiac arrhythmia, night blindness, photophobia, edema of the face/fingers/feet/calves, tubular vision, weight gain.

Incidence Unknown

Cloudy/bloody urine, hypertension.

Adverse Reactions Generally Not Requiring Medical Attention

As the body adapts to the medication, such adverse reactions may resolve on their own; healthcare professionals can also provide methods for prevention/mitigation. If adverse reactions persist, cause distress, or if you have any questions, consult a healthcare professional:

Common: Belching, hematochezia after defecation, altered taste, hair color changes, decreased appetite, weight loss, constipation, difficulty moving, fear, fatigue, ageusia, myalgia, arthralgia, rash, sore throat, gastric discomfort, oral swelling and inflammation, perianal swelling and pain, voice changes.

Some patients may experience adverse reactions not listed above. If any abnormalities occur, consult a healthcare professional promptly.

Missed Dose

If you miss a dose, take it as soon as you remember. If the next scheduled dose is due in less than 12 hours, skip the missed dose and continue with the original schedule. Do not take a double dose to make up for the missed one.

If more than 12 hours remain until the next scheduled dose after missing a dose, take the missed dose as soon as possible and take the next dose at the original scheduled time.