What are the interactions of cabozantinib with other medications

Cabozantinib is a multi-kinase inhibitor that is often used in combination with other drugs in clinical treatment, but its interaction with other drugs is a cause for concern.

What are the interactions of cabozantinib with other medications

Interactions with other drugs may affect the efficacy of cabozantinib and even pose potential risks.

Interactions with anticoagulant drugs

Cabozantinib may increase the risk of bleeding when combined with an anticoagulant drug, such as warfarin. This is because cabozantinib may affect the activity of thrombin, leading to a prolonged clotting time, which can increase bleeding tendency.

Interactions with antihypertensive drugs

When cabozantinib is used in combination with antihypertensive drugs (eg, ACE inhibitors, ARBs), it can cause blood pressure to be too low. Cabozantinib has the effect of inhibiting angiotensin II receptor activity, which may exacerbate the antihypertensive effect of antihypertensive drugs, which in turn can cause hypotensive symptoms.

Interactions with chemotherapy drugs

When cabozantinib is used in combination with chemotherapy drugs (eg, paclitaxel, doxorubicin), it may increase toxicity. This is because cabozantinib may affect the metabolism and excretion of chemotherapy drugs, causing the drug to accumulate in the body, which can increase toxicity.

How to reduce the risk of cabozantinib interactions with other drugs

Understanding and taking appropriate steps can help reduce the risk of cabozantinib interactions with other medications.

A detailed history is sought

Before using cabozantinib, the physician should ask the patient a detailed drug history, including prescription drugs, over-the-counter drugs, health products, etc., so as to detect potential interaction risks in time.

Adjust the dose of the medication

For drugs with known interactions, doctors should adjust the dose of the drug to reduce side effects based on the patient's specific situation. If necessary, consider withholding certain medications.

Regular monitoring and follow-up

During the use of cabozantinib, patients should have regular blood routine, liver and kidney function tests, etc., so as to detect adverse reactions caused by drug interactions in time. Doctors should follow up and adjust treatment based on changes in the patient's condition.

The interaction between cabozantinib and other drugs is a problem that cannot be ignored in clinical treatment. For the sake of patient safety, physicians should fully understand the mechanism of cabozantinib interactions and take appropriate measures to reduce the risk. Patients should also actively cooperate with the doctor's treatment recommendations, and have regular monitoring and follow-up to maintain their health.