Dosage of Selinexor

1.Recommended Dosage for Multiple Myeloma

In Combination with Bortezomib and Dexamethasone (XVd).The recommended dosage of Selinexor is 100 mg taken orally once weekly on Day 1 of each week until disease progression or unacceptable toxicity in combination.

2.Recommended Dosage for Diffuse Large B-Cell Lymphoma

The recommended dosage of Selinexor is 60 mg taken orally on Days 1 and 3 of each week until disease progression or unacceptable toxicity. 

3.Dosage Modification for Adverse Reactions

Recommended Selinexor dosage reduction steps are presented in Table 1. 

Table 1: Selinexor Dosage Reduction Steps for Adverse Reactions

Recommended dosage modifications for hematologic adverse reactions in patients with multiple myeloma and DLBCL are presented in Table 2 and Table 3, respectively. Recommended dosage modifications for nonhematologic adverse reactions are presented in Table 4. 

Table 2: Selinexor Dosage Modification Guidelines for Hematologic Adverse Reactions in Patients with Multiple Myeloma

Table 3: Selinexor Dosage Modification Guidelines for Hematologic Adverse Reactions in Patients with Diffuse Large B-Cell Lymphoma

Table 4: Selinexor Dosage Modification Guidelines for Non-Hematologic Adverse Reactions

from FDA，2022.07