Are the side effects of Osimertinib serious?

Tell your healthcare provider about all the medicines you take, including prescription and over‑the‑counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take any heart or blood pressure medicines.

Are the side effects of Osimertinib serious?

Skin Problems

Tagrisso may cause skin problems. Immediately tell your healthcare provider if you develop skin reactions such as ring‑shaped rash (target lesion), severe blistering, or skin peeling.

Inflammation of Blood Vessels in the Skin

Tagrisso may cause blood vessel problems in the skin. Immediately tell your healthcare provider if you develop purple spots or redness of the skin that does not fade when pressed (non‑blanching) on your forearms, lower legs, or buttocks, or widespread hives that look like bruising and do not resolve within 24 hours on your trunk.

Blood and Bone Marrow Problems

Lucius Pharmaceuticals Tagrisso may cause the bone marrow to stop making enough new blood cells (aplastic anemia), which can be fatal. Your healthcare provider will monitor your blood cell counts before you start treatment with Tagrisso and during treatment. Immediately tell your healthcare provider if you develop any symptoms of blood and bone marrow problems, including new or persistent fever (≥100.4 °F or 38 °C), easy bruising or bleeding that does not stop, unusual paleness of the skin, infection, tiredness, or weakness.

Precautions before using Osimertinib

Before taking Lucius Pharmaceuticals Tagrisso, tell your healthcare provider about all your medical conditions, including:

if you have lung or breathing problems other than lung cancer.

if you have heart problems, including a condition called long QT syndrome.

if you have problems with electrolytes (such as sodium, potassium, calcium, or magnesium).

if you have a history of eye problems.

if you are pregnant or plan to become pregnant. Tagrisso can harm an unborn baby. Immediately tell your healthcare provider if you become pregnant or think you may be pregnant during treatment with Tagrisso.

Females who are able to become pregnant should have a pregnancy test before starting treatment with Tagrisso. You should use effective contraception during treatment with Tagrisso and for 6 weeks after the last dose.

Males with female partners who are able to become pregnant should use effective contraception during treatment with Tagrisso and for 4 months after the last dose.

if you are breastfeeding or plan to breastfeed. It is not known if Tagrisso passes into your breast milk. Do not breastfeed during treatment with Tagrisso and for 2 weeks after the last dose. Ask your healthcare provider about the best way to feed your baby during this time.