Does Mitotane have side effects?

Mitotane is a drug dedicated to the treatment of adrenocortical carcinoma (inoperable), hyperplasia, and tumor-induced hypercortisolism, and its core mechanism is to inhibit adrenal cortical function.

Does Mitotane have side effects?

Mitotane is an antineoplastic drug that has certain side effects when treating specific diseases. Here are examples of common side effects of mitotane:

1. Nervous system reactions

It presents with symptoms such as dizziness, drowsiness, and headache. Vertigo may be due to drugs affecting the functional activity of the vestibular nuclei, hypothalamus, and cerebellum; Headaches may be due to increased intracranial pressure.

It also includes confusion, muscle tremors, etc.

2. Skin reactions

Mitotane may cause an allergic reaction, leading to inflammation of the skin. Common symptoms include erythema, blisters, itching, etc., and in severe cases, scaling or erosion may occur.

3. Other side effects

Mitotane may cause an increase in blood pressure, which requires regular monitoring and, if necessary, antihypertensive medications. A sharp drop in blood pressure may occur when changing positions, leading to symptoms such as dizziness and dizziness.

In addition to the above symptoms, side effects such as hemorrhagic cystitis, depression, blurred vision, diplopia, hematuria, and proteinuria can also occur, among which renal impairment is a more serious side effect, and patients should pay attention to it.

Renal impairment produced by mitotane

Mitotane may cause some damage to renal function during treatment, which is mainly due to the toxic effect of its metabolites and the interference of drugs with the function of renal tubular epithelial cells.

Mitotane interferes with the function of tubular epithelial cells, resulting in a decrease in glomerular filtration rate and decreased tubular resorption. This disturbance may further affect the kidneys' balanced regulation of electrolytes and water, leading to renal impairment.

Preventive measures for the production of renal impairment by mitotane

Prevention of renal impairment in mitotane requires a combination of factors.

1. Strengthen health education

Improve patients' awareness and adherence to mitotane treatment and enhance self-management ability. Patients should be aware of the side effects and precautions of the drug and actively cooperate with the doctor's treatment plan.

2. Regular follow-up

Patients should visit the hospital regularly for follow-up tests, including assessment of kidney function, electrolyte levels, and drug efficacy. Depending on the results of follow-up, doctors will adjust treatment or give necessary supportive care.

The risk of renal impairment can be reduced and the effectiveness of treatment can be improved through comprehensive preventive measures for patients.

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