What is the dosage of Mitotane?

Mitotane can inhibit the function of adrenal cortical cells, especially the activity of core cholesterol side-chain lyase, which can precisely block the synthesis of steroid hormones (including cortisol), thereby reducing the synthesis of steroid hormones.

What is the dosage of Mitotane?

The dosage of Mitotane varies from person to person and usually needs to be determined based on the patient's specific situation and the doctor's guidance. In general, the dosage of Mitotane is recommended to start with a small dose and gradually increase to the maximum tolerated dose.

Adult patients may have a lower initial dose of 3 to 4 oral doses.

As treatment progresses, the doctor will gradually adjust the dose according to the patient's response and tolerance, but the dosage of Mitotane needs to be individualized according to the specific situation of the patient and should be carried out under the guidance of the doctor to ensure that it is safe and effective.

Clinical manifestations of primary hyperaldosteronism due to adrenocortical carcinoma

The clinical manifestations of primary hyperaldosteronism caused by adrenocortical carcinoma mainly include the following aspects:

1. High blood pressure

Patients often have persistent hypertension that is difficult to control with conventional antihypertensive medications. This is because excessive aldosterone secretion leads to sodium retention and fluid volume expansion, which in turn inhibits the renin-angiotensin system.

2. Low blood potassium

The sodium-preserving and potassium-excretion effect of aldosterone lowers serum potassium levels, and patients may present with symptoms such as muscle weakness, periodic paralysis, and limb numbness. Decreased potassium levels in the blood can also affect heart function, leading to arrhythmias such as paroxysmal supraventricular tachycardia and, in severe cases, ventricular fibrillation.

3. Neuromuscular dysfunction

Hypokalemia may also cause dysfunction of the neuromuscular system, manifested as muscle weakness and paralysis, especially when exertion, cold, and tension are more likely to be induced.

Coping with primary hyperaldosteronism due to adrenocortical carcinoma

For primary hyperaldosteronism caused by adrenocortical carcinoma, the main measures include:

1. Surgical treatment

Early removal of the tumor, especially if extensive metastases have not occurred, surgery is the treatment of choice. After surgery, blood potassium, blood pressure, and other indicators should be monitored, and the treatment plan should be adjusted according to the situation.

2. Medication

For patients who are inoperable or postoperatively, an aldosterone antagonist such as spironolactone may be used to correct hypokalemia and hypertension. At the same time, electrolytes and renal function should be monitored regularly, and the dose of the drug should be adjusted according to the condition.

3. Symptomatic treatment

Neuromuscular symptoms caused by hypokalemia require prompt potassium supplementation. In addition, it is necessary to control blood pressure and prevent cardiovascular and cerebrovascular complications.

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