What are the drug interactions of capivasertib?

Although capivasertib offers a new treatment option for specific cancers, its efficacy and safety are highly susceptible to the impact of concomitant medications, making it crucial to clarify its drug interactions.

What are the drug interactions of capivasertib?

While some drugs should not be used together at all, in other cases, two different drugs may need to be administered in combination even if interactions might occur. In such instances, your doctor may wish to adjust the dosage or implement other preventive measures. It is particularly important to inform your doctor whether you are taking any of the following medications while on this drug. The interactions listed below are selected based on their potential significance and are not exhaustive.

Concurrent use of this drug with any of the following medications is not recommended. Your doctor may decide not to treat you with this drug or adjust some of your other medications you are currently taking.

Bacillus Calmette-Guérin (BCG) vaccine (live attenuated).

Dengue tetravalent vaccine (live attenuated).

Measles virus vaccine (live attenuated).

Mumps virus vaccine (live attenuated).

Rubella virus vaccine (live attenuated).

Smallpox-monkeypox vaccine.

Typhoid vaccine.

Varicella virus vaccine (live attenuated).

Yellow fever vaccine.

Other Interactions of Capivasertib

Certain medications should not be used during or around meal times, nor should they be taken with specific types of food, as interactions may occur. The concurrent use of alcohol or tobacco with some medications may also trigger interactions. The interactions listed below are selected based on their potential significance and are not exhaustive.

Concurrent use of this drug with grapefruit juice is generally not recommended, but it may be unavoidable in some cases. If co-administration is necessary, your doctor may adjust the dosage or frequency of this drug, or provide you with special instructions regarding the consumption of food, alcohol, or tobacco.

Storage and Handling of Capivasertib

1. Store the medication in its original, labeled container, in a dry place at room temperature (unless otherwise directed by your doctor or pharmacist).

2. Do not store this drug in pill organizers.

3. Keep the container out of the reach of children and pets.

4. Dosage Preparation:If a caregiver prepares your dose, they should consider wearing gloves, or pour the pills directly from the container into a bottle cap, small cup, or your palm. Avoid direct contact with the pills. Wash hands thoroughly before and after administering the dose. Pregnant or breastfeeding women should not prepare your dose.

5. Medication Disposal:Consult your oncology team for instructions on how to dispose of unused medication. Do not flush it down the toilet or discard it in regular household garbage.