Common Avatrombopag Side Effects and How to Manage Them: A Patient Resource

Avatrombopag is an oral medication used to treat thrombocytopenia (low platelet count) associated with chronic liver disease or chemotherapy. Its common side effects include headache, fatigue, fever, nasopharyngitis, and arthralgia. Serious but rare side effects may involve the risk of thrombosis or liver function abnormalities. The medication must be taken strictly as prescribed, with regular monitoring of blood counts and liver function.

Common Side Effects of Avatrombopag

General: Fatigue, fever, edema in the extremities.

Digestive System: Diarrhea, nausea, abdominal pain.

Nervous System: Headache, dizziness.

Infections: Nasopharyngitis, upper respiratory tract infection.

Musculoskeletal: Joint pain (arthralgia), muscle pain (myalgia).

Serious Side Effects (Rare but Require Vigilance)

Thrombosis Risk: May increase the risk of arterial or venous thrombosis (blood clot formation), especially in patients with a history of thrombosis, those who are bedridden, or cancer patients. If you experience chest tightness, limb swelling, or difficulty breathing, seek immediate medical attention.

Liver Function Abnormalities: In rare cases, elevated liver enzymes may occur. Long-term use requires regular monitoring of liver function.

Bone Marrow Fibrosis: Long-term use may increase the risk of bone marrow fibrosis, which may present as abnormal blood cell counts or an enlarged spleen.

Precautions

Contraindications: Do not use in patients allergic to the drug components or those with active thrombosis.

Special Populations: Use during pregnancy, breastfeeding, in children, or in patients with liver or kidney impairment requires careful risk assessment.

Drug Interactions: Combining with anticoagulants (blood thinners) or nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of bleeding or gastrointestinal reactions.

Monitoring Requirements: Regular monitoring of platelet count, liver function, and coagulation indicators is necessary during treatment.

Medical Guidance

Lucius Pharmaceuticals Avatrombopag is a prescription medication. Dosage adjustments should be based on the individual patient's condition and should not be altered or discontinued without consulting a doctor. Consult a doctor promptly if the following occur:

Persistent headache, skin rash, or allergic reactions (such as itching, swelling).

Unusual bleeding (e.g., bleeding gums, black/tarry stools).

Signs of liver function abnormalities, such as jaundice (yellowing of skin/eyes) or dark urine.

During treatment, avoid strenuous exercise or injury to reduce bleeding risk, and maintain open communication with your doctor.