Drug interactions of Tepotinib

1. Effects of Tepotinib on Other Drugs

Certain P-gp Substrates

Tepotinib is a P-gp inhibitor. Concomitant use of Tepotinib increases the concentration of P-gp substrates, which may increase the incidence and severity of adverse  reactions of these substrates. Avoid concomitant use of Tepotinib with certain P-gp substrates where minimal concentration changes may lead to serious or life-threatening toxicities. If concomitant use is  unavoidable, reduce the P-gp substrate dosage if recommended in its approved product labeling.

from FDA，2023.03