Side effects requiring immediate medical attention with Enasidenib

During treatment with Enasidenib, in addition to the expected therapeutic effects, some adverse effects may also occur. While not all side effects happen, some may require medical intervention. If patients experience any of the following side effects while taking the medication, it is recommended to contact a doctor immediately.

Side effects requiring immediate medical attention with Enasidenib

1. Common side effects

These include agitation, bluish discoloration of the lips, nails, or skin (cyanosis), bone pain, chest pain, chills, confusion, cough, coughing up pink frothy sputum, decreased responsiveness, decreased urine output, depression, difficulty breathing, rapid or noisy breathing, dizziness, eye pain, fainting, fast heartbeat, fever, general feeling of discomfort, headache, hostility, increased sweating, irregular breathing (too fast, too slow, or shallow), irritability, lightheadedness, loss of consciousness, muscle or joint pain, muscle twitching, nausea, pale skin, rapid weight gain, shallow breathing, seizures, severe drowsiness, sore throat, swelling in the neck, groin, or armpits, swelling of the arms, feet, or lower legs, swelling of the face, ankles, or hands, unusual sleepiness, lethargy, tiredness, weakness, or feeling sluggish, and yellowing of the skin or eyes.

2. Other side effects

Some side effects of Enasidenib typically do not require medical attention and may gradually resolve as the body adjusts to the medication.

Side effects requiring medical consultation with Enasidenib

Common side effects

These include changes in taste, decreased appetite, diarrhea, loss of taste, and vomiting.

Side effect management for healthcare professionals

1. Systemic adverse reactions

The most common adverse reactions (incidence ≥30%) of any grade include elevated bilirubin, decreased blood calcium and potassium, nausea, diarrhea, vomiting, and decreased appetite.

2. Hepatobiliary system

Very common (≥10%): Elevated total bilirubin (81%).

3. Metabolic system

Very common (≥10%): Decreased blood calcium (74%), decreased blood potassium (41%), decreased appetite (34%), decreased blood phosphorus (27%).

Common (1%-10%): Tumor lysis syndrome, weight loss.

4. Gastrointestinal system

Very common (≥10%): Nausea (50%), diarrhea (43%), vomiting (34%).

Common (1%-10%): Abdominal pain.

5. Hematologic system

Very common (≥10%): Differentiation syndrome (14%), non-infectious leukocytosis (12%).

6. Nervous system

Very common (≥10%): Dysgeusia (taste disturbance) (12%).

7. Skin system

Common (1%-10%): Rash.

8. Genitourinary system

Common (1%-10%): Elevated uric acid.

9. Other

Common (1%-10%): Fever, peripheral edema.

10. Renal system

Common (1%-10%): Renal insufficiency.

11. Respiratory system

Common (1%-10%): Respiratory failure, dyspnea (difficulty breathing), hypoxemia (low blood oxygen), pulmonary edema, acute respiratory distress syndrome.