Drug interactions of Tazemetostat

1 Effect of Other Drugs on Tazemetostat

Strong or Moderate CYP3A Inhibitors

Coadministration of Tazemetostat with a strong or moderate CYP3A inhibitor increases tazemetostat plasma  concentrations, which may increase the frequency or severity of adverse  reactions. Avoid coadministration of strong or moderate CYP3A inhibitors with Tazemetostat. If  coadministration of strong or moderate CYP3A inhibitors cannot be avoided, reduce Tazemetostat dose.  

Strong or Moderate CYP3A Inducers

Coadministration of Tazemetostat with a strong CYP3A inducer decreases tazemetostat plasma concentrations, and coadministration of Tazemetostat with a moderate CYP3A inducer may  also decrease tazemetostat plasma concentrations. The decrease in tazemetostat plasma concentration may  decrease the efficacy of Tazemetostat. Avoid coadministration of moderate or strong CYP3A inducers with Tazemetostat.  

2 Effect of Tazemetostat on Other Drugs

CYP3A Substrates

Coadministration of Tazemetostat with CYP3A substrates, including hormonal contraceptives, can result in  decreased concentrations and reduced efficacy of CYP3A substrates.

from FDA，2024.08