Drug interactions of Sunitinib

1 Effect of Other Drugs on Sunitinib

Strong CYP3A4 Inhibitors

Co-administration with strong CYP3A4 inhibitors may increase sunitinib plasma concentrations. Select an alternate concomitant medication with no or minimal enzyme inhibition  potential. Consider a dose reduction for Sunitinib when it is co-administered with strong CYP3A4 inhibitors.  

Strong CYP3A4 Inducers

Co-administration with strong CYP3A4 inducers may decrease sunitinib plasma concentrations. Select an alternate concomitant medication with no or minimal enzyme induction  potential. Consider a dose increase for Sunitinib when it must be co-administered with CYP3A4 inducers.  

2 Drugs that Prolong QT Interval

Sunitinib is associated with QTc interval prolongation. Monitor the QT interval with ECGs more frequently in patients who require treatment  with concomitant medications known to prolong the QT interval.

from FDA，2021.08