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Indications of Ribociclib

1 Early Breast Cancer

Ribociclib is indicated in combination with an aromatase inhibitor for the adjuvant treatment of adults with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative stage II and III early breast cancer at high risk of recurrence.  

2 Advanced or Metastatic Breast Cancer

Ribociclib is indicated for the treatment of adults with HR-positive, HER2-negative advanced or metastatic breast cancer in combination with:

• an aromatase inhibitor as initial endocrine-based therapy; or

• fulvestrant as initial endocrine-based therapy or following disease progression on endocrine therapy.

from FDA,2024.09

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