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Indications of Quizartinib

Quizartinib is indicated in combination with standard cytarabine and anthracycline induction and cytarabine consolidation, and as maintenance monotherapy following consolidation chemotherapy, for the treatment of adult patients with newly diagnosed acute myeloid leukemia (AML) that is FLT3 internal  tandem duplication (ITD)-positive as detected by an FDA-approved test.  

Limitations of Use

Quizartinib is not indicated as maintenance monotherapy following allogeneic hematopoietic stem cell transplantation (HSCT); improvement in overall survival with Quizartinib in this setting has not been demonstrated.

from FDA,2023.07

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