What are the drug interactions of Pralsetinib?

While certain medications should not be used together at all, in other cases, two different drugs may need to be administered in combination even if interactions are likely to occur.

What are the drug interactions of Pralsetinib?

In such cases, your doctor may need to adjust the dosage or take other necessary preventive measures. It is particularly important to inform your doctor whether you are taking any of the following medications while on this treatment. The interactions selected below are based on their potential significance and are not exhaustive.

Concurrent use of this drug with the following live attenuated vaccines is not recommended: Bacillus Calmette-Guérin (BCG) vaccine, tetravalent dengue live attenuated vaccine, measles live attenuated vaccine, mumps live attenuated vaccine, rubella live attenuated vaccine, smallpox and monkeypox vaccine, typhoid vaccine, varicella live attenuated vaccine, and yellow fever vaccine. Your doctor may decide not to treat you with this drug or to modify some of your other medications.

Does Pralsetinib interact with food or beverages?

Pralsetinib should be taken on an empty stomach. Avoid taking Pralsetinib within 2 hours before or 1 hour after meals.

Grapefruit interacts with Pralsetinib. It is crucial to avoid consuming grapefruit or drinking grapefruit juice while taking Pralsetinib. This is because grapefruit may interfere with your body’s ability to metabolize Pralsetinib, leading to elevated drug levels and an increased risk of side effects.

It is currently unknown whether alcohol consumption affects Pralsetinib, but both Pralsetinib and alcohol may increase your risk of bleeding. It is advisable to limit alcohol intake.

Precautions for Pralsetinib

Your blood pressure may increase during treatment with Pralsetinib. Your doctor will closely monitor your blood pressure and may prescribe antihypertensive medications if hypertension develops.

You may experience tumor lysis syndrome (TLS; a condition caused by the rapid breakdown of cancer cells, which can lead to renal failure and other complications) during Pralsetinib treatment. To help reduce the risk of TLS, your doctor may advise you to drink plenty of water before and during treatment, as well as each time the dosage is increased. In addition, your doctor will administer medications to help prevent this side effect before you start treatment and during the treatment course. Contact your doctor immediately if you experience any of the following TLS symptoms: fever, chills, nausea, vomiting, confusion, shortness of breath, seizures, irregular heartbeat, dark or cloudy urine, unusual fatigue, or muscle or joint pain.