What precautions should I be aware of when taking ivosidenib?

Ivosidenib is indicated only for patients with acute myeloid leukemia (AML), cholangiocarcinoma, or myelodysplastic syndromes (MDS) whose tumors harbor an isocitrate dehydrogenase-1 (IDH1) mutation. Your doctor will perform testing to confirm the presence of this mutation.

What precautions should I be aware of when taking ivosidenib?

Your doctor must schedule regular follow-up visits to ensure the medication is working effectively. Blood and urine tests may be required to monitor for potential adverse reactions.

Taking this medication may increase your risk of developing a condition called differentiation syndrome, which can be life-threatening. This typically occurs within 1 day to 3 months after starting treatment. Contact your doctor immediately if you experience any of the following symptoms: fever, cough, difficulty breathing, swelling in your arms or legs, swelling around your neck, groin, or armpits, rapid weight gain, or bone pain.

This drug may also cause a serious reaction known as tumor lysis syndrome (TLS). Seek immediate medical attention if you notice changes in the amount or frequency of urination, rapid weight gain, muscle or joint pain, swelling in your feet or lower legs, or unusual fatigue or weakness.

What should I pay attention to while taking this medication?

1. Your condition will be closely monitored throughout your treatment with this drug.

2. You may feel unwell during treatment. This is not uncommon, as chemotherapy medications affect not only cancer cells but also healthy cells. Report any side effects to your healthcare team. Unless instructed otherwise by your medical team, continue taking the full prescribed course even if you feel unwell.

3. You may need periodic blood tests during treatment.

4. Inform your healthcare team if you are pregnant or could become pregnant. Taking this medication during pregnancy may cause severe birth defects. Use effective contraception during treatment. Your healthcare team can help you choose an appropriate method of birth control.

5. Do not breastfeed during treatment and for at least 1 month after your last dose.

6. This medication may cause infertility. If you have concerns about your fertility, discuss them with your healthcare team.

How should ivosidenib be stored?

Keep the medication out of reach of children and pets.

Store it at room temperature between 20°C and 25°C (68°F to 77°F) in a dry place. Keep the container tightly closed. Do not discard the desiccant packet inside the bottle—it helps keep the medication dry. Dispose of any unused medication after the expiration date.