Dosage of Deucravacitinib

1.Recommended Evaluations and Immunizations Prior to Treatment  Initiation

Evaluate patients for active and latent tuberculosis (TB) infection prior to initiating treatment with Deucravacitinib. If positive, start treatment for TB prior to Deucravacitinib use. Update immunizations according to current immunization guidelines.

2.Recommended Dosage

The recommended dosage of Deucravacitinib is 6 mg taken orally once daily, with or without food. Do not crush, cut, or chew the tablets.

3.Recommended Dosage in Patients with Hepatic Impairment

Deucravacitinib is not recommended in patients with severe hepatic impairment (Child-Pugh C). No dosage adjustment is needed for patients with mild to moderate hepatic impairment.

from FDA，2022.09