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Dosage of Aprocitentan

1 Recommended Dosage

The recommended dosage of Aprocitentan is 12.5 mg orally once daily.

Swallow tablets whole. Aprocitentan may be taken with or without food.

If a dose is missed, skip the missed dose and take the next dose at the regular time. Do  not take two doses on the same day.

2 Pregnancy Testing in Females of Reproductive Potential

Initiate treatment with Aprocitentan in females of reproductive potential only after confirmation  of a negative pregnancy test. Patients should exclude pregnancy with negative pregnancy  tests monthly during treatment and one month after discontinuation of treatment with Aprocitentan.

from FDA,2024.03

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