Dosage of Adagrasib

1. Recommended Dosage 

The recommended dosage of Adagrasib is 600 mg orally twice daily until disease progression or  unacceptable toxicity.  Take Adagrasib at the same time every day with or without food. Swallow tablets whole. Do not chew, crush or split tablets. If vomiting occurs after taking Adagrasib, do not take an additional dose. Resume dosing at the  next scheduled time. If a dose is inadvertently missed, it should be skipped if greater than 4 hours have elapsed from  the expected dosing time. Resume dosing at the next scheduled time.

2. Dosage Modifications for Adverse 

Reactions Recommended dose reductions for adverse reactions are outlined in Table 1. If adverse reactions  occur, a maximum of two dose reductions are permitted. Permanently discontinue Adagrasib in  patients who are unable to tolerate 600 mg once daily.

The recommended dosage modifications for adverse reactions are provided in Table 2. 

FDA,2022.12