What are the drug interactions of Sotorasib?

Sotorasib, a targeted therapeutic agent for advanced non-small cell lung cancer (NSCLC) patients harboring the KRAS G12C mutation, exerts its efficacy by specifically inhibiting the activity of the KRAS protein, thereby impeding cellular proliferation and dissemination, providing a novel treatment option for patients.

What are the drug interactions of Sotorasib?

Considerable attention must be paid to the pharmacological interactions of Sotorasib when administered to patients, to preempt any untoward reactions.

1. Acid Suppressants

The solubility of Sotorasib is intricately linked to pH levels. Co-administration of Sotorasib with gastric acid inhibitors may potentially diminish its concentration, thus impacting therapeutic efficacy. Proton pump inhibitors (PPIs), H2 receptor antagonists, and locally acting acid suppressants all have the potential to affect the absorption and efficacy of Sotorasib. To mitigate this interaction, physicians typically advise patients to administer Sotorasib ingestion either 4 hours before or 10 hours after locally acting acid suppressants.

2. Potent CYP3A4 Inducers

Sotorasib acts as a substrate for the CYP3A4 enzyme, rendering its metabolic processes susceptible to the influence of other drugs that modulate CYP3A4 activity. Potent CYP3A4 inducers such as Rifampicin, Rifapentine, Phenytoin, Carbamazepine, Barbital, and St. John's Wort may decrease the concentration of Sotorasib, thus compromising its therapeutic efficacy. Patients are advised to refrain from concomitant use of these potent CYP3A4 inducers when utilizing Sotorasib.

Sotorasib is a prescription medication that necessitates adherence to the guidance and recommendations of doctors to avoid indiscriminate use. Additionally, along with understanding the pharmacological interactions of Sotorasib, attention must also be directed towards the appropriate storage of the medication, as proper storage practices are pivotal for maintaining its stability and potency.

How is Sotorasib stored?

Regarding the storage of Sotorasib, as outlined in the medication package insert, the following recommendations are pertinent:

1. Temperature Regulation

Sotorasib should be stored at room temperature between 20-25°C. Extreme temperatures, be they excessively high or low, can compromise the stability of the medication; elevated temperatures may lead to degradation or spoilage of the drug, while low temperatures might result in crystallization impacting drug efficacy.

2. Light Protection

Ultraviolet rays from sunlight can potentially degrade the active components of the medication, thereby diminishing its potency. Sotorasib should thus be shielded from light exposure to prevent light-induced degradation.

3. Airtightness and Dryness

Sotorasib should be stored in a sealed container to prevent the ingress of moisture and impurities from the air, which could compromise the purity of the medication. Additionally, it is imperative to store Sotorasib in a dry environment to prevent degradation due to humidity.

[Warm tips] Patients utilizing Sotorasib should acquire comprehensive knowledge about its pharmacological interactions and storage guidelines and utilize the medication judiciously under the supervision of healthcare providers. Regular follow-up visits to healthcare facilities are essential for assessing treatment efficacy and monitoring adverse reactions.