What conditions can Selpercatinib treat?

Selpercatinib is a targeted therapy drug that is mainly used to inhibit cancer caused by mutations in the RET gene. It has shown remarkable efficacy in controlling the spread of cancer cells and is suitable for the treatment of a variety of tumor types.

What conditions can Selpercatinib treat?

Selpercatinib has been approved for marketing in China, and the indications are not limited to cholangiocarcinoma and lymphoid tumors.

1. RET fusion-positive thyroid cancer

Treatment of patients 2 years of age and older, with RET gene fusion positive confirmed by an FDA-approved test, and patients with advanced or metastatic thyroid cancer who do not respond to radioactive iodine therapy.

2. Other RET fusion-positive solid tumors

Treatment for patients aged 2 years and older, with positive RET gene fusions confirmed by FDA-approved testing, progression after prior therapy, or no satisfactory alternative therapy.

Is Selpercatinib used in special populations?

When it comes to medication for special populations, patients should pay special attention to the following:

1. Patients with renal insufficiency

Patients with mild to severe renal insufficiency do not need to adjust the dose when using Selpercatinib. Doctors should monitor the patient's kidney function, paying attention to the effects of the drug on the individual.

2. Patients with liver injury

Patients with mild to moderate hepatic impairment do not need to adjust the dose of Selpercatinib. Patients with severe hepatic impairment should reduce the dose. Doctors need to monitor these patients more frequently.

What are the adverse effects of Selpercatinib?

During the use of the drug, patients may experience the following adverse reactions:

1. Stomatitis

The oral mucosa may be sore, red, swollen or painful, and in severe cases, it may interfere with eating and speaking. Patients may use non-alcoholic mouthwashes and local anesthetic medications to reduce oral discomfort, while spicy or acidic foods should be avoided.

2. Dry eye syndrome

Dry, uncomfortable eyes are common symptoms that can cause blurred or stinging vision. Patients can alleviate dry eye symptoms by using artificial tears or moisturizing eye drops, and an ophthalmologist should be consulted if necessary for further treatment.

[Warm tips] If you experience a rash, difficulty breathing, or other allergic symptoms after taking the drug, please stop the medication immediately and seek medical help. Follow your doctor's advice for regular follow-up appointments to monitor the effectiveness of your treatment and adjust the dosage as needed.