How effective is the treatment of Selpercatinib?

Selpercatinib is the first targeted drug specifically targeting RET gene mutations and was approved by the FDA in 2020; By inhibiting the activity of RET kinase and blocking the growth signal of tumor cells, it has achieved good efficacy in the treatment of a variety of cancers.

How effective is the treatment of Selpercatinib?

In terms of therapeutic efficacy, Selpercatinib has shown the following significant advantages.

1. Patients with previously treated RET fusion-positive non-small cell lung cancer

Fourteen patients had a response to treatment of intracranial lesions, accounting for 88% of patients with CNS metastases at baseline or 6% of the total population. Thirty-nine percent of patients had intracranial remission for more than 12 months, demonstrating the durability of treatment.

2. Newly treated patients with RET fusion-positive non-small cell lung cancer

The objective response rate was 63%, similar to that of the combination chemotherapy group, showing response to treatment. Of the 5 patients with brain metastases, 4 (80%) had a response to treatment, showing an effect of treatment. Thirty-eight percent of treatment-naïve patients had an intracranial remission of more than 12 months, comparable to that of the previous treatment group.

What are the adverse effects of Selpercatinib?

There may be some side effects associated with the use of Selpercatinib, and the following are the common adverse effects.

1. Hair loss

Hair loss is relatively common in treatment and can take a toll on the patient's psychological and social life. Hair loss is usually temporary, and patients can choose to wear a wig or use other cosmetic methods to cope with this change.

2. Stomatitis

Symptoms of stomatitis, such as ulcers, pain, and redness of the oral mucosa, may make people feel uncomfortable when eating and talking. Patients should maintain oral hygiene, use non-irritating mouthwashes to reduce symptoms, and avoid spicy, acidic foods.

What is the dosage of Selpercatinib?

For the dosage and dosage of Selpercatinib, please understand the following dosage recommendations.

1. Recommended dosage

Selpercatinib is taken with meals at approximately the same time every day.

Swallow whole tablets without crushing, chewing, breaking or dissolving. If you miss taking the dose for more than 4 hours, or if you vomit after taking the medication, skip this dose and take the next dose as planned.

2. Recommended dose for patients with severe liver impairment

For patients with severe hepatic impairment whose total bilirubin exceeds 3 times the upper limit of normal and is accompanied by any elevated AST, the recommended dose is 9 mg, with a schedule of use (intermittent or continuous) specified according to the indication.

[Warm tips] Provide a comprehensive personal history and information about all medications you are taking, including prescription drugs, over-the-counter medications, and health supplements, to help your doctor make accurate treatment decisions.