How is cerpatinib used?

Selpercatinib helps control the proliferation and metastasis of cancer cells by blocking the RET signaling pathway. The drug, which is indicated for patients over 12 years of age, was first marketed in the United States in 2020 and has now been approved for domestic marketing.

How is Selpercatinib used?

When using Selpercatinib for treatment, please refer to the following medication guidelines.

1. Cholangiocarcinoma (with FGFR2 fusion)

The dose is 9 mg once daily for the first 14 days of each 21-day cycle.

2. Medullary/lymphoid tumor (with FGFR1 rearrangement)

The dose is 4.5 mg once daily for the first 14 days of each 21-day cycle.

3. Dose reduction

For cases that require dose reduction, patients should continue to take 4.5 mg once daily for the entire duration of each 21-day cycle.

How effective is the treatment of Selpercatinib?

Selpercatinib has shown significant results in the treatment of the following aspects.

Results in patients with RET fusion-positive non-small cell lung cancer

1. Intracranial lesion response

Fourteen patients responded to intracranial lesions, demonstrating the effectiveness of treatment for brain metastases.

2. Duration of intracranial remission

Intracranial remission lasted more than 12 months in 39% of patients, suggesting that in some patients, treatment can control brain metastases in the short term and achieve long-term intracranial stability.

What are the adverse drug reactions of Selpercatinib?

There are some side effects that may result from the use of Selpercatinib, and common reactions are listed below.

1. Hyperphosphatemia

Similar to the adverse effects of cholangiocarcinoma, hyperphosphatemia is a condition in which phosphate levels in the blood rise, which can cause muscle cramps, bone pain, and other problems. Patients need to have their blood phosphate levels checked regularly and their diet and medications adjusted under the guidance of their doctor to manage their symptoms.

2. Nail poisoning

Patients may have discoloration, brittleness, or delamination of their nails, affecting the appearance and function of the nails. This adverse effect may be uncomfortable for the patient, and it is important to protect the nails as much as possible in daily life, keep the hands clean, and avoid exposure to harsh chemicals.

[Warm tips] Take the medicine strictly according to the dosage requirements on the doctor's or drug instructions. Do not increase or decrease the dosage without authorization, as it may affect the effectiveness of the medication or increase the risk of side effects.