What Are the Daily Precautions for Pralsetinib?

Please keep all scheduled appointments with your doctor and the laboratory on time. Your doctor will conduct laboratory tests before treatment to determine whether your cancer is eligible for treatment with pralsetinib. The doctor will also arrange specific laboratory tests before, during, and after treatment to monitor your body's response to pralsetinib.

What Are the Daily Precautions for Pralsetinib?

Before taking pralsetinib, you should inform your healthcare providers of the following information:

Inform your healthcare providers of all your health conditions, as well as any prescription or over-the-counter drugs, vitamins/minerals, herbal products, and other supplements you are taking. This will help them determine if pralsetinib is suitable for you.

Please inform your healthcare providers if you have any of the following conditions: lung or respiratory problems, high blood pressure, bleeding disorders, or liver problems.

Adverse Reactions of Pralsetinib

Interactions with Other Drugs and Supplements

Pralsetinib may interact with other drugs and supplements. Before taking pralsetinib, inform your healthcare providers of any prescription or over-the-counter drugs, vitamins/minerals, herbal products, and other supplements you are using.

Wound Healing Issues

Pralsetinib may impair your body's ability to heal wounds. If you have a scheduled or emergency surgery, or suffer any trauma while taking pralsetinib, please inform your healthcare providers immediately.

Planned Surgery

If you have a planned surgery, discuss it with your healthcare providers in advance. Pralsetinib may increase the risk of severe bleeding, and it is necessary to discontinue the drug at least five days before certain surgeries. Do not stop taking pralsetinib without consulting your healthcare providers first.

Pregnancy

Pralsetinib may cause harm to the unborn fetus. If you are pregnant or planning to become pregnant, please inform your healthcare providers. You must not be pregnant before starting pralsetinib treatment. If you could become pregnant, use effective non-hormonal contraceptive methods (e.g., condoms) during treatment with pralsetinib and for at least two weeks after the last dose. If you are assigned male at birth and have a partner who could become pregnant, use effective contraceptive measures during treatment with pralsetinib and for at least one week after the last dose.

Infertility

Pralsetinib may cause fertility problems. If you are concerned about this, discuss it with your healthcare providers.

Lactation

It is unknown whether pralsetinib is excreted in human breast milk. If you are breastfeeding or planning to breastfeed, please inform your healthcare providers. You should not breastfeed during treatment with pralsetinib and for at least one week after the last dose.

Storage and Handling of Pralsetinib

Store this medication in its original container, tightly closed, and out of the reach of children. Store it at room temperature, away from excessive heat and moisture (do not store in the bathroom).

Keep all medications out of sight and reach of children, as many containers are not child-resistant. Always ensure the safety cap is locked. Store medications in a safe place—one that is high up and out of their sight and reach.

Dispose of unused medications in a manner that is out of the reach of pets, children, and others. Do not flush this medication down the toilet. Use a medication take-back program. Consult your pharmacist for information on medication take-back programs in your community.