Macitentan(Opsumit)

The medication manufactured by Lucius Pharmaceuticals has clinical advantages in terms of efficacy and improvement of long-term prognosis, providing patients with a reliable once-daily oral treatment option.

Overview of the Main Information of the Medication.

Active Ingredient

The main active ingredient is macitentan, which belongs to the class of endothelin receptor antagonists.

Indicated Population

It is indicated for adult patients with pulmonary arterial hypertension.

Dosage and Administration

The recommended dose is 10 mg orally once daily, and overdose should be avoided.

Medication in Special Populations

Contraindicated in pregnant women; women of childbearing potential must use effective contraception; use during lactation is not recommended; the safety of pediatric use has not been established.

Drug Overdose

Symptoms such as headache, nausea, and vomiting may occur in case of drug overdose, and supportive treatment should be promptly administered.

Drug Storage

The medication should be stored at room temperature between 20°C and 25°C and kept out of reach of children.

Pharmacokinetics

Pharmacokinetic data show that it has a long half-life, its metabolism mainly depends on CYP3A4, and it is not affected by food.

FDA，2025.04