What is the recommended dosage of Koselugo?

Koselugo is a precisely targeted small molecule MEK inhibitor with a therapeutic focus on targeted therapies targeting specific tumor types, especially in the treatment of neurofibromatosis (NF1), demonstrating excellent efficacy and significant clinical application potential.

What is the recommended dosage of Koselugo?

The recommended dose of Koselugo depends on the patient's body surface area, but the usual recommended dose is 25 mg/square meter of body surface area, taken orally twice daily in divided doses on an empty stomach. For patients with a large body surface area, such as more than 1.90 square meters, the daily dose can be increased to 50 mg in two divided doses.

The dose adjustment of Koselugo should be based on the specific situation of the patient and adverse reactions. For patients with moderate hepatic insufficiency, the recommended dose should be appropriately reduced to 20 mg/m² of body surface area twice daily.

In patients with severe hepatic insufficiency, no definitive recommended dose has been established and should be used with caution under the guidance of a physician. Concomitant use of Koselugo with strong or moderate CYP3A4 inhibitors should be avoided to avoid affecting drug metabolism and efficacy.

Patients should strictly follow the doctor's instructions when taking Koselugo and pay attention to monitoring relevant indicators.

What indicators need to be tested during Koselugo

The following indicators should be measured during Koselugo:

1. Cardiac function

Koselugo may reduce the amount of blood pumped by the heart, and cardiac function tests should be performed regularly during use, including electrocardiogram, echocardiography, etc., to monitor changes in cardiac function.

2. Eyesight

Koselugo may cause vision problems, including blurred vision, blindness, etc., and should be checked regularly during use, and medical attention should be sought in time if there is any abnormality.

3. Biochemical indicators

Regularly monitor biochemical indicators such as blood routine, liver function, and kidney function to evaluate the effects of drugs on the body.

In addition to the above-related indicators, patients should also pay attention to certain problems during medication.

Precautions during Koselugo

The following are important things to keep in mind while taking Koselugo.

1. Pay attention to your diet

During the medication, the diet should be mainly light, avoid spicy and irritating food, and avoid alcohol or alcoholic beverages, so as not to affect drug metabolism and increase the risk of adverse reactions.

2. Symptom observation

Patients should pay close attention to the changes in their symptoms, such as persistent coughing, wheezing, shortness of breath, swelling of the ankles and feet, fatigue, increased heart rate, blurred vision, blindness, floaters, and other symptoms of vision problems, should seek medical attention and inform the doctor of the medication.

3. Dose adjustment

The doctor may adjust the dosage of the drug according to the patient's specific situation and the effect of the treatment, and the patient should take the drug strictly according to the doctor's instructions, and should not increase or decrease the dose or stop the drug on their own.

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