What are the side effects of using Exkivity?

Exkivity is an innovative third-representative dermal growth factor receptor (EGFR) tyrosine kinase inhibitor specifically designed for the treatment of patients with non-small cell lung cancer (NSCLC) harboring EGFR exon 20 insertion mutations.

What are the side effects of using Exkivity?

Exkivity is a potent EGFR inhibitor that may cause a series of adverse reactions in the treatment of non-small cell lung cancer, among which "heart-rate-corrected QT (QTc) interval prolongation" is an adverse reaction of high concern. The QT interval is the distance on the ECG from the beginning of the QRS complex to the end of the T wave, representing the time required for the entire process of ventricular muscle depolarization and repolarization. The QTc interval is the heart rate-corrected QT interval that is used to more accurately assess changes in the QT interval.

Exkivity may lead to prolongation of the QTc interval, which increases the risk of arrhythmias, including serious arrhythmias such as torsade de pointes, which have the potential to progress to ventricular fibrillation and even be life-threatening. When treating with Exkivity, a series of precautions must be taken to reduce this risk.

How to reduce the risk of QTc interval prolongation

Before starting treatment, doctors should perform a thorough electrocardiogram (ECG) to understand the patient's underlying QTc interval. During treatment, ECG monitoring should be done at regular intervals (eg, bi-weekly or monthly) to detect prolongation of the QTc interval in good time.

Electrolyte abnormalities are also an important factor in QTc interval prolongation, and patients need to be closely monitored for electrolyte levels, particularly potassium and magnesium concentrations.

Countermeasures for prolonged QTc interval during treatment

If a significantly prolonged QTc interval is found during monitoring or if there are signs or symptoms of life-threatening arrhythmias, your doctor may recommend discontinuation of Exkivity therapy or dose adjustment. Severe QTc prolongation or arrhythmias may require permanent discontinuation of Exkivity and appropriate treatment.

Patients should pay close attention to their physical condition during the treatment and seek medical attention immediately if they have symptoms that may be related to arrhythmias, such as palpitations, chest tightness, dizziness, etc.

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