What should I pay attention to when using Exkivity

Exkivity capsules can be used by adults with non-small cell lung cancer that has spread to other parts of the body (metastatic) and cannot be removed with surgery, whose disease has worsened while on or after chemotherapy with platinum, and has cancer has epidermal growth factor receptor (EGFR) exon 20 insertion mutation.

What should I pay attention to when using Exkivity

EXKIVITY can cause diarrhea, which can be severe. In the pooled EXKIVITY safety population, diarrhea occurred in 93% of patients, including 20% in Grade 3 and 0.4% in Grade 4. The median time to first onset of diarrhea was 5 days but diarrhea occurred within 24 hours after administration of EXKIVITY. In the 48% of patients whose diarrhea resolved, the median time to resolution was 3 days. Diarrhea may lead to dehydration or electrolyte imbalance, with or without renal impairment. Treat diarrhea promptly.

Clinical manifestations of diarrhea caused by Exkivity

During the use of EXKIVITY, patients should closely observe their physical condition, especially the occurrence of adverse reactions such as diarrhea. 

1. Dehydration and electrolyte abnormalities

Diarrhea may cause dehydration with symptoms such as thirst, dry skin, and decreased urine output. At the same time, diarrhea may also cause electrolyte abnormalities, such as low potassium and sodium, which can further affect the patient's physical health.

2. Abnormal kidney function

In rare cases, diarrhea may be accompanied by abnormalities in renal function, manifested by changes in indicators such as elevated creatinine. This may be due to diarrhea's fluid losses and electrolyte imbalances affecting kidney function.

Measures for diarrhea caused by Exkivity

For diarrhea caused by EXKIVITY, the following measures can be taken:

1. Dietary modifications

During diarrhea, patients should avoid eating greasy, spicy, and other irritating foods to avoid aggravating diarrhea symptoms. Foods that are easy to digest and rich in nutrients, such as rice porridge and noodles, can be consumed in moderation.

2. Hydration

Diarrhea can cause patients to lose large amounts of fluids, so adequate hydration should be maintained to maintain water and electrolyte balance. It is recommended to drink about 2 liters of clear liquids per day, such as lukewarm water, light saltwater, or fruit juice drinks.

【Warm tips】When patients buy generic drugs, they should choose formal channels to ensure the quality and safety of the drugs. Avoid purchasing counterfeit products from informal sources.