What is the dosage of crizotinib

This article discusses the standardized use and precautions of the drug crizotinib.

What is the dosage of crizotinib

Reasonable drug dosage control is the key to achieving therapeutic efficacy.

Standard dosage regimen

Adults are recommended to take 250mg capsules twice daily. Clinical studies have shown that this dose can better control the pathological progression of specific diseases while maintaining the balance of blood concentration. For special 200mg capsules, the number of capsules taken at a time should be adjusted according to the doctor's instructions.

Principle of dose adjustment

When liver function is abnormal or drug metabolism is impaired, the dose needs to be lowered to 200 mg per day. Some patients may have visual disturbances or gastrointestinal reactions, and a phased dose reduction should be performed under the guidance of a physician. Regular ECG reviews are required during treatment to prevent the potential risk of QT interval prolongation.

Long-term medication management

For patients who have been on treatment for more than 12 months, quarterly metabolic function assessment is recommended. The drug should be stored away from light and moisture, and the capsule should be used within 30 days after opening. The market price of a single box (60 capsules) is about $130, and there are price differences between different packaging specifications.

Key elements of standardized medication

Scientific drug use needs to consider many factors.

Identification of contraindications

It is contraindicated in pregnant women and in patients with severe hepatic dysfunction. Patients who are receiving other targeted therapies should wait at least 48 hours before starting this drug regimen. Patients who are lactose intolerant should inform their treating physician in advance.

Take your medication correctly

Capsules should be swallowed whole, with warm water for best results. It is recommended to fix the daily time of medication, and the interval between the two doses is strictly maintained for 12 hours. If the dose is missed, it can be retaken within 4 hours, and the current dose should be skipped.

Efficacy monitoring indicators

Imaging evaluation is performed every 6 weeks at the beginning of treatment, and the stabilization period is extended to every 12 weeks. Blood tests should focus on neutrophil count and aminotransferase levels. Some patients may present with fatigue symptoms, which usually resolve gradually after 2 to 3 weeks.

Standardized medication requires close cooperation between doctors and patients, and a complete management system is formed from dose control to process monitoring. Through an individualized treatment plan and regular medical evaluation, the effect of the drug can be maximized and the patient can achieve a good prognosis.