​Who is Alpelisib suitable for?

Alpelisib fills a gap in the treatment of HR/HER2- breast cancer, particularly in patients with PIK3CA mutations, and the combination of fulvestrant improves efficacy.

Who is Alpelisib suitable for?

Determining the appropriate population for Apelix is critical to ensuring the precision and effectiveness of treatment.

Apellix in combination with fulvestrant is indicated for the treatment of hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, PIK3CA-mutated advanced or metastatic breast cancer in postmenopausal women and men. This regimen is particularly useful for patients who have not achieved adequate response to previous endocrine regimens.

These advanced or metastatic breast cancers are confirmed by FDA-approved tests to ensure that treatment options are targeted. This treatment has shown good results in specific populations, but it may also be accompanied by some adverse reactions during use. Understanding these potential side effects is critical for patients.

What are the adverse effects of Alpelisib?

During treatment, patients may experience some adverse reactions, and resolving and managing these reactions is critical to the smooth progress of the patient's treatment.

1. Diarrhea

Medications can cause digestive reactions, leading to frequent diarrhea. Diarrhea may be accompanied by abdominal pain or stomach upset, and long-term diarrhea may also lead to dehydration.

2. Rash

The drug can trigger an allergic skin reaction, such as a rash, itching or scaling. In severe cases, medications may need to be adjusted or stopped to relieve symptoms.

Management of adverse effects is essential to improve treatment outcomes, and the following are especially important when using Apellis.

What should I do during the administration of Alpelisib?

Please pay special attention to the following precautions when using Alpelisib.

1. Diarrhea or colitis

During Apellix treatment, patients should be monitored for symptoms such as abdominal pain, mucus, or bloody stools. Depending on the severity, the medication may need to be interrupted, reduced, or stopped. When diarrhea develops, patients should immediately start antidiarrheal therapy and increase fluid intake, while informing their doctor.

2. Embryo-fetal toxicity

Apellix can be harmful to the fetus, and women of childbearing potential should use contraception during treatment and for a week after the last dose. Male patients should also use a condom to protect their partner during this time. Before treatment, patients should be aware of the potential risks of the drug to the fetus.

Understanding these considerations can help you better manage your treatment and protect your patient's health.

[Warm tips] Maintaining a balanced diet and adequate sleep, as well as regular exercise, can help improve overall health and healing outcomes.