​What is the dosage of Alpelisib?

Patients with HR/HER2- advanced breast cancer harboring PIK3CA mutations were significantly delayed in disease progression under the combination of Alpelisib and fulvestrant.

What is the dosage of Alpelisib?

The dosing and dosing recommendations for apellix should be adjusted on an individual basis and should be determined by the physician.

1. Recommended dose

The standard dose of Alpelisib is 300 mg once daily with two 150 mg film-coated tablets. It is recommended to take it with a meal to improve the absorption of the drug.

2. Missed dose treatment

If you miss a dose of apelix, you can take that dose with a meal within 9 hours of the usual time of taking the dose. If it is more than 9 hours, skip the dose for the day and take it at the normal time the next day.

The Dosage and Dosage Instructions for Alpelisib provide general advice. Patients should discuss with their doctor how to adjust the use of the method according to their individual situation. Medication modification for special populations is also important when using Apelix.

Is Alpelisib used for special populations?

In certain populations, the regimen of apellix may need to be specifically modified.

1. It is used by elderly patients

In the trial, patients over 65 years of age had a higher incidence of hyperglycaemia, but there was no significant difference in efficacy. There are insufficient data in patients over 75 years of age to fully assess efficacy.

2. Renal impairment

The effect of severe renal impairment on Alpelisib is unclear. Patients with mild to moderate renal impairment do not need to adjust the dose.

Medication modification in special populations is essential for successful treatment. Below we will describe the possible adverse effects when using Apelix.

What are the adverse effects of Alpelisib?

There may be some side effects associated with the use of Apelix, and the following are the common adverse reactions.

1. γ-glutamyl transferase (GGT) is elevated

Drugs can trigger abnormal liver function, leading to an increase in GGT levels. Liver function needs to be monitored to avoid potential liver damage.

2. Alanine aminotransferase (ALT) is elevated

Drugs can cause liver cell damage, which manifests as elevated levels of ALT. Liver function tests need to be done regularly to avoid serious liver problems.

Understanding these adverse effects can help identify and address problems in a timely manner during treatment and better manage the treatment process.

[Warm tips] Regular check-ups, maintain communication with doctors, and pay attention to physical changes. If you have any discomfort or doubts, consult your doctor promptly.